Pre-Clinical Research
1015 South Mercer Avenue  ●  Bloomington, Illinois 61701  ●  Toll Free 800.997-CINF  ●  Telephone 309.663.1522  ●  Facsimile 309.663.2344
The Central Illinois Neuroscience Foundation maintains an active, highly competitive pre-clinical research program at Illinois State University which concentrates on molecular mechanisms underlying acute stroke and spinal cord injury.

Mechanisms of Focal Cerebral Ischemia
Stroke is the third leading cause of premature death in adults and the leading cause of adult disability.  Research in this area focuses on identifying the mechanisms of ischemia, factors that influence secondary injury, and testing novel compounds and treatments for stroke.  Findings in the laboratory show that hyperthermia increases neuronal death, compromises microcirculation, exacerbates ischemic brain edema, enhances the breach of blood-brain-barrier and diminishes the efficacy of thrombolysis.

Inflammatory Reaction & Neuronal Death in Spinal Cord Injury
Inflammation plays an essential role in the injury processes following cerebral ischemic brain injury and traumatic spinal cord injury.  We have examined pro-inflammatory cytokines, interleukin beta-1 and tumor necrosis factor alpha, as well as their mRNA in the brain and spinal cord following injury.  Findings from these studies show that these cytokines and their mRNA increase rapidly and last for several days.  Research also focuses on whether glial reaction is involved in neuronal death following brain and spinal cord injury.  Further, we are also investigating how cyclin dependent kinase (CDK)-5 regulates neuronal apoptosis, neuronal survival and neuronal differentiation.

Chen Xu Wang, M.D., Ph.D.
Director, PreClinical Research, CINF
Research Assistant Professor, ISU

For more information about the CINF Research Laboratory at ISU, please click here.

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